Use of integrated FDG-PET/CT in sarcoidosis

Clin Imaging. Jul-Aug 2008;32(4):269-73. doi: 10.1016/j.clinimag.2007.11.005.

Abstract

We studied five patients with mediastinal lymph node enlargement suggestive of malignant lymphoma, lung cancer, or sarcoidosis. Integrated [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) was performed on all patients. Sarcoidosis can be a pitfall in PET/CT imaging, which may lead to false-positive results of malignancy. Increased FDG uptake in mediastinal lymph nodes is often comparable with malignant lymphoma or lymph node metastases. Histological confirmation of the lesions should be mandatory, except for patients in whom sarcoidosis can be accurately confirmed by other diagnostic methods.

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Lung Diseases / diagnostic imaging*
  • Lung Neoplasms / diagnostic imaging
  • Lymph Nodes / diagnostic imaging
  • Male
  • Mediastinum / diagnostic imaging
  • Middle Aged
  • Positron-Emission Tomography*
  • Radiopharmaceuticals*
  • Sarcoidosis / diagnostic imaging*
  • Tomography, X-Ray Computed*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18