Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice

Biosci Biotechnol Biochem. 2008 Jul;72(7):1932-5. doi: 10.1271/bbb.70636. Epub 2008 Jul 7.

Abstract

The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening, and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents*
  • Cattle
  • Colitis / chemically induced
  • Colitis / drug therapy*
  • Colitis / pathology
  • Dextran Sulfate
  • Lactoperoxidase / administration & dosage
  • Lactoperoxidase / pharmacology*
  • Lactoperoxidase / therapeutic use
  • Mice
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Dextran Sulfate
  • Lactoperoxidase