Novel Association of ABO Histo-Blood Group Antigen With Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women

PLoS Genet. 2008 Jul 4;4(7):e1000118. doi: 10.1371/journal.pgen.1000118.

Abstract

While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / genetics*
  • ABO Blood-Group System / immunology
  • ABO Blood-Group System / metabolism
  • Female
  • Genetic Linkage
  • Genetic Variation
  • Genome, Human*
  • Humans
  • Intercellular Adhesion Molecule-1 / blood*
  • Intercellular Adhesion Molecule-1 / genetics*
  • Myocardial Infarction / immunology
  • Myocardial Infarction / metabolism
  • Polymorphism, Single Nucleotide
  • Solubility
  • Women's Health

Substances

  • ABO Blood-Group System
  • Intercellular Adhesion Molecule-1