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. 2007;50:95-7.

Effect of Taurine on the Concentrations of Glutamate, GABA, Glutamine and Alanine in the Rat Striatum and Hippocampus

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  • PMID: 18605241

Effect of Taurine on the Concentrations of Glutamate, GABA, Glutamine and Alanine in the Rat Striatum and Hippocampus

Svetlana M Molchanova et al. Proc West Pharmacol Soc. .

Abstract

Taurine, a non-protein amino acid, acts as an osmoregulator and inhibitory neuromodulator in the brain. Here we studied the effects of intraperitoneal injections of taurine on the concentrations of glutamate and GABA, and their precursors, glutamine and alanine, in the rat striatum and hippocampus. Injections of 0.25, 0.5 and 1 g/kg taurine led to a gradual increase in taurine tissue concentrations in both hippocampus and striatum. Glutamate and GABA also increased in the hippocampus, but not in the striatum. Glutamine increased and alanine decreased markedly in both brain structures. The results corroborate the neuromodulatory role of taurine in the brain. Taurine administration results in an imbalance in inhibitory and excitatory neurotransmission in the glutamatergic (hippocampus) and GABAergic (striatum) brain structures, affecting more markedly the neurotransmitter precursors.

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    Herbert MR. Herbert MR. Neuropsychol Rev. 2011 Mar;21(1):70-1. doi: 10.1007/s11065-011-9159-9. Epub 2011 Jan 19. Neuropsychol Rev. 2011. PMID: 21246288 No abstract available.

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