Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese

Clin Chem Lab Med. 2008;46(4):523-7. doi: 10.1515/CCLM.2008.111.


Background: Alkaline phosphatase (ALP) is a biomarker for hepatobiliary and skeletal diseases. It is also raised in sepsis. In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population.

Methods: Plasma ALP and CRP were measured in 205 subjects (110 men, 95 women; age 55.2+/-11.6 years) in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 cohort.

Results: The blood levels of ALP and CRP were significantly correlated (r=0.30, p<0.001), which was due to a significant correlation in women (r=0.43, p<0.001). In a multivariate model, CRP level was related to ALP (beta=0.18, p=0.008). After adjusting for confounding factors and other liver enzymes, the relationship between ALP and CRP remained significant in women (beta=0.28, p=0.019), but in men, ALP was not an independent determinant of CRP levels.

Conclusions: ALP may be another marker of systemic inflammation, especially in women. Whether it provides clinical information additional to CRP requires further study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alkaline Phosphatase / blood*
  • C-Reactive Protein / biosynthesis*
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / ethnology
  • Female
  • Hong Kong
  • Humans
  • Inflammation
  • Liver / pathology
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Reference Values
  • Risk Factors
  • Sex Factors


  • C-Reactive Protein
  • Alkaline Phosphatase