Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors

Biochemistry (Mosc). 2008 May;73(5):562-72. doi: 10.1134/s000629790805009x.


The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / blood*
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / immunology
  • Autoantigens / blood
  • Autoantigens / genetics
  • Autoantigens / immunology
  • Gene Expression Regulation
  • Humans
  • Microarray Analysis*
  • Neoplasms / blood*
  • Neoplasms / diagnosis*
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Serologic Tests


  • Antigens, Neoplasm
  • Autoantigens