Abstract
Conclusion:
The results of this study suggest that treatment with radical scavengers has the potential to become an effective new therapy for age-related hearing loss.
Objective:
To assess the efficacy of treatment with radical scavengers for age-related hearing loss.
Subjects and methods:
Rebamipide (300 mg/day), alpha-lipoic acid (60 mg/day), and vitamin C (600 mg/day) were given orally for at least 8 weeks to 46 elderly patients with age-related hearing loss.
Results:
Hearing levels after treatment were significantly improved at all frequencies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alanine / analogs & derivatives*
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Alanine / therapeutic use
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Ascorbic Acid / therapeutic use*
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Audiometry, Pure-Tone
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Drug Therapy, Combination
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Ear, Inner / drug effects
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Female
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Free Radical Scavengers / therapeutic use*
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Humans
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Male
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Pilot Projects
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Presbycusis / drug therapy*
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Quinolones / therapeutic use*
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Sensory Thresholds / drug effects
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Thioctic Acid / therapeutic use*
Substances
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Free Radical Scavengers
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Quinolones
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Thioctic Acid
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rebamipide
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Alanine
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Ascorbic Acid