Abstract
A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the compounds (2) displayed moderate antitubercular activity while two compounds (2) and (4) inhibited the fungal growth at 25 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antitubercular Agents / chemical synthesis
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Aza Compounds / pharmacology
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Bacteria / drug effects
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Cycloaddition Reaction
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Fungi / drug effects
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Isoindoles / chemical synthesis*
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Isoindoles / chemistry
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Isoindoles / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
Substances
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Anti-Infective Agents
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Antifungal Agents
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Antitubercular Agents
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Aza Compounds
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Isoindoles