Moenomycin: an inhibitor of c55-isoprenoid-alcohol kinase from Staphylococcus aureus

Biochim Biophys Acta. 1976 Oct 22;444(3):783-8.

Abstract

The effect of a variety of structurally diverse antibiotics on C55-isoprenoid-alcohol kinase (EC 2.7.1.66) from Staphylococcus aureus has been examined. Only moenomycin was found to be inhibitory (Ki = 0.2 mM). Moenocinol, the C25 lipid component of moenomycin, did not serve as a substrate of the kinase reaction and was less inhibitory than the intact antibiotic. It is concluded that the observed inhibition may be due to the structural similarity between C55-isoprenylmonophosphate and the substituted moenocinol moiety of moenomycin.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Fatty Alcohols
  • Glycolipids / pharmacology
  • Kinetics
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphotransferases / antagonists & inhibitors*
  • Staphylococcus aureus / enzymology*
  • Terpenes

Substances

  • Anti-Bacterial Agents
  • Fatty Alcohols
  • Glycolipids
  • Terpenes
  • Phosphotransferases
  • Phosphotransferases (Alcohol Group Acceptor)
  • undecaprenol kinase