Hodgkin Lymphoma-Associated Hemophagocytic Syndrome: A Disorder Strongly Correlated With Epstein-Barr Virus

Clin Infect Dis. 2008 Aug 15;47(4):531-4. doi: 10.1086/590152.

Abstract

The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Epstein-Barr Virus Infections / complications*
  • Epstein-Barr Virus Infections / virology
  • Female
  • Herpesvirus 4, Human / isolation & purification*
  • Hodgkin Disease / complications*
  • Hodgkin Disease / virology*
  • Humans
  • Lymphohistiocytosis, Hemophagocytic / epidemiology
  • Lymphohistiocytosis, Hemophagocytic / etiology*
  • Lymphohistiocytosis, Hemophagocytic / pathology
  • Lymphohistiocytosis, Hemophagocytic / virology*
  • Male
  • Middle Aged