The mitochondrial proteome: from inventory to function

Cell. 2008 Jul 11;134(1):22-4. doi: 10.1016/j.cell.2008.06.043.


Mitochondria are central to cellular energetics, metabolism, and signaling. In this issue, Pagliarini et al. (2008) report the largest compendium of mammalian mitochondrial proteins to date. Together with proteomic studies in yeast, this study represents an important step toward the systematic characterization of the mitochondrial proteome and of mitochondrial diseases.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Mass Spectrometry
  • Mice
  • Mitochondria / chemistry*
  • Mitochondrial Proteins / analysis*
  • Proteome*


  • Mitochondrial Proteins
  • Proteome