mTOR and Akt signaling in cancer: SGK cycles in

Mol Cell. 2008 Jul 11;31(1):6-8. doi: 10.1016/j.molcel.2008.06.007.

Abstract

In a recent issue of Molecular Cell, Hong et al. (2008) describe an alternative mechanism by which mTOR promotes cell-cycle progression; it phosphorylates and activates SGK, which in turn phosphorylates the cell-cycle inhibitor p27, promoting its cytoplasmic retention.

Publication types

  • Comment

MeSH terms

  • Cell Cycle
  • Cyclin-Dependent Kinase Inhibitor p27 / metabolism
  • Enzyme Activation
  • Humans
  • Immediate-Early Proteins / metabolism*
  • Neoplasms / enzymology*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphorylation
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases

Substances

  • Immediate-Early Proteins
  • Cyclin-Dependent Kinase Inhibitor p27
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • serum-glucocorticoid regulated kinase