Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives

J Nutr Health Aging. Aug-Sep 2008;12(7):433-50. doi: 10.1007/BF02982704.

Abstract

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with increasing age, being a major component in the development of frailty. Current knowledge on its assessment, etiology, pathogenesis, consequences and future perspectives are reported in the present review. On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / metabolism
  • Aging / physiology*
  • Exercise / physiology*
  • Frail Elderly
  • Humans
  • Muscle, Skeletal / anatomy & histology
  • Muscle, Skeletal / physiology
  • Muscle, Skeletal / physiopathology*
  • Muscular Atrophy* / epidemiology
  • Muscular Atrophy* / etiology
  • Muscular Atrophy* / pathology
  • Muscular Atrophy* / prevention & control