Glucose induction pathway regulates meiosis in Saccharomyces cerevisiae in part by controlling turnover of Ime2p meiotic kinase

FEMS Yeast Res. 2008 Aug;8(5):676-84. doi: 10.1111/j.1567-1364.2008.00406.x. Epub 2008 Jul 8.

Abstract

Several components of the glucose induction pathway, namely the Snf3p glucose sensor and the Rgt1p and Mth1p transcription factors, were shown to be involved in inhibition of sporulation by glucose. The glucose sensors had only a minor role in regulating transcript levels of the two key regulators of meiotic initiation, the Ime1p transcription factor and the Ime2p kinase, but a major role in regulating Ime2p stability. Interestingly, Rgt1p was involved in glucose inhibition of spore formation but not inhibition of Ime2p stability. Thus, the glucose induction pathway may regulate meiosis through both RGT1-dependent and RGT1-independent pathways.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Colony Count, Microbial
  • DNA-Binding Proteins
  • Gene Expression Profiling
  • Glucose / metabolism*
  • Intracellular Signaling Peptides and Proteins
  • Meiosis*
  • Monosaccharide Transport Proteins / genetics
  • Monosaccharide Transport Proteins / metabolism
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases
  • RNA Stability
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Spores, Fungal / physiology
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • IME1 protein, S cerevisiae
  • Intracellular Signaling Peptides and Proteins
  • Monosaccharide Transport Proteins
  • Nuclear Proteins
  • RGT1 protein, S cerevisiae
  • Repressor Proteins
  • SNF3 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors
  • Protein Kinases
  • IME2 protein, S cerevisiae
  • Protein-Serine-Threonine Kinases
  • Glucose