Neutralization of lethality and proteolytic activities of Malayan pit viper (Calloselasma rhodostoma) venom with North American Virginia opossum (Didelphis virginiana) serum

Toxicon. 2008 Jul;52(1):186-9. doi: 10.1016/j.toxicon.2008.04.163. Epub 2008 May 29.

Abstract

Malayan pit viper (Calloselasma rhodostoma) envenomation is a major health problem in South East Asia. During envenomation, venom components mainly affect the hemostatic system. The sera from the North American Virginia opossums (Didelphis virginiana) were able to neutralize the venom of the Malayan pit viper. These natural inhibitors could be explored as potential therapeutics against envenomations of a variety of venomous snake species in different geographical habitats.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Crotalid Venoms / antagonists & inhibitors*
  • Didelphis / blood*
  • Lethal Dose 50

Substances

  • Crotalid Venoms