Genetic predictors of depressive symptoms in cardiac patients

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):381-8. doi: 10.1002/ajmg.b.30824.


Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega-3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Canada / epidemiology
  • Depression / complications
  • Depression / genetics*
  • Endothelial Cells / pathology
  • Fatty Acids, Omega-3 / genetics*
  • Fatty Acids, Omega-3 / metabolism
  • Female
  • France / ethnology
  • Gene Frequency
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Haplotypes
  • Heart Diseases / epidemiology
  • Heart Diseases / genetics*
  • Homozygote
  • Humans
  • Inflammation / genetics*
  • Introns
  • Linear Models
  • Linkage Disequilibrium
  • Logistic Models
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / genetics
  • Odds Ratio
  • Platelet Aggregation / genetics*
  • Polymorphism, Single Nucleotide
  • Predictive Value of Tests
  • Prevalence
  • von Willebrand Factor / genetics


  • Fatty Acids, Omega-3
  • Genetic Markers
  • von Willebrand Factor