Peroxisomes: minted by the ER

Curr Opin Cell Biol. 2008 Aug;20(4):393-400. doi: 10.1016/j.ceb.2008.05.008. Epub 2008 Jul 9.

Abstract

Peroxisomes are one of numerous organelles in a eukaryotic cell; they are small, single-membrane-bound vesicles involved in cellular metabolism, particularly fatty acid degradation. Transport of metabolites and co-factors in and across the membrane is taken care of by specific transporters. Peroxisome formation and maintenance has been debated for a long time: opinions swinging from autonomous to ER-derived organelles. Only recently it has been established firmly that the site of origin of peroxisomes is the ER. It implies that a new branch of the endomembrane system is open to further characterization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endoplasmic Reticulum / physiology*
  • Humans
  • Peroxisomes / physiology*