Reorganization of visual processing in macular degeneration: replication and clues about the role of foveal loss

Vision Res. 2008 Aug;48(18):1910-9. doi: 10.1016/j.visres.2008.05.020. Epub 2008 Jul 11.

Abstract

We previously reported large-scale reorganization of visual processing (i.e., activation of "foveal" cortex by peripheral stimuli) in two individuals with loss of foveal input from macular degeneration [Baker, C.I., Peli, E., Knouf, N., & Kanwisher, N. G. (2005). Reorganization of visual processing in macular degeneration. Journal of Neuroscience, 25(3), 614-618]. Here, we replicate this result in three new individuals. Further, we test the hypothesis that this reorganization is dependent on complete loss of foveal input. In two other individuals with extensive retinal lesions but some foveal sparing we found no evidence for reorganization. We conclude that large-scale reorganization of visual processing in MD occurs only in the complete absence of functional foveal vision.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Age of Onset
  • Aged
  • Brain Mapping / methods
  • Female
  • Fixation, Ocular
  • Fovea Centralis / physiopathology*
  • Humans
  • Macular Degeneration / physiopathology*
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neuronal Plasticity*
  • Photic Stimulation / methods
  • Scotoma / physiopathology
  • Visual Cortex / physiopathology*
  • Visual Pathways / physiopathology