Comment on "Genetically determined differences in learning from errors"

Science. 2008 Jul 11;321(5886):200; author reply 200. doi: 10.1126/science.1156079.

Abstract

Klein et al. (Reports, 7 December 2007, p. 1642) used individuals with a polymorphism adjacent to the dopamine receptor 2 gene as naturally occurring models for reduced brain dopamine receptor density in a probabilistic learning task. We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange.

Publication types

  • Comment

MeSH terms

  • Alleles
  • Brain / metabolism
  • Cloning, Molecular
  • Humans
  • Learning*
  • Polymorphism, Genetic*
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / physiology
  • Proteins / genetics
  • Proteins / physiology
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D2 / metabolism
  • Signal Transduction

Substances

  • Proteins
  • Receptors, Dopamine D2
  • TTC12 protein, human
  • ANKK1 protein, human
  • Protein-Serine-Threonine Kinases