Animal Models of Acute Lung Injury

Am J Physiol Lung Cell Mol Physiol. 2008 Sep;295(3):L379-99. doi: 10.1152/ajplung.00010.2008. Epub 2008 Jul 11.

Abstract

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Bleomycin / toxicity
  • Chemokines / physiology
  • Disease Models, Animal
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / injuries
  • Endotoxins / toxicity
  • Humans
  • Hyperoxia / complications
  • Immunity, Innate
  • Lung / drug effects
  • Lung / pathology
  • Lung / physiopathology
  • Lung Injury*
  • Mice
  • Nitric Oxide / physiology
  • Oleic Acid / toxicity
  • Pulmonary Alveoli / drug effects
  • Pulmonary Alveoli / injuries
  • Receptors, Chemokine / physiology
  • Respiration, Artificial / adverse effects
  • Respiratory Distress Syndrome, Adult / etiology
  • Respiratory Distress Syndrome, Adult / pathology
  • Respiratory Distress Syndrome, Adult / physiopathology
  • Risk Factors
  • Sepsis / complications
  • Species Specificity

Substances

  • Chemokines
  • Endotoxins
  • Receptors, Chemokine
  • Bleomycin
  • Oleic Acid
  • Nitric Oxide