Strategies for carbohydrate recognition by the mannose 6-phosphate receptors

Glycobiology. 2008 Sep;18(9):664-78. doi: 10.1093/glycob/cwn061. Epub 2008 Jul 11.


The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Carbohydrate Metabolism* / physiology
  • Crystallography, X-Ray
  • Glycoproteins / chemistry
  • Glycoproteins / metabolism
  • Glycoproteins / physiology
  • Humans
  • Mannosephosphates / chemistry
  • Mannosephosphates / metabolism
  • Models, Biological
  • Models, Molecular
  • Molecular Sequence Data
  • Oligosaccharides / metabolism
  • Protein Binding
  • Receptor, IGF Type 2 / chemistry
  • Receptor, IGF Type 2 / metabolism*
  • Sequence Homology, Amino Acid


  • Glycoproteins
  • Mannosephosphates
  • Oligosaccharides
  • Receptor, IGF Type 2
  • mannose-6-phosphate