The auxin influx carrier LAX3 promotes lateral root emergence

Nat Cell Biol. 2008 Aug;10(8):946-54. doi: 10.1038/ncb1754. Epub 2008 Jul 11.


Lateral roots originate deep within the parental root from a small number of founder cells at the periphery of vascular tissues and must emerge through intervening layers of tissues. We describe how the hormone auxin, which originates from the developing lateral root, acts as a local inductive signal which re-programmes adjacent cells. Auxin induces the expression of a previously uncharacterized auxin influx carrier LAX3 in cortical and epidermal cells directly overlaying new primordia. Increased LAX3 activity reinforces the auxin-dependent induction of a selection of cell-wall-remodelling enzymes, which are likely to promote cell separation in advance of developing lateral root primordia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arabidopsis
  • Arabidopsis Proteins / physiology*
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Gene Expression Regulation, Plant
  • Indoleacetic Acids / pharmacology*
  • Membrane Transport Proteins / physiology*
  • Plant Growth Regulators / pharmacology
  • Plant Roots / cytology
  • Plant Roots / growth & development*


  • Arabidopsis Proteins
  • Carrier Proteins
  • Indoleacetic Acids
  • LAX3 protein, Arabidopsis
  • Membrane Transport Proteins
  • Plant Growth Regulators