Improved biocompatibility and pharmacokinetics of silica nanoparticles by means of a lipid coating: a multimodality investigation

Nano Lett. 2008 Aug;8(8):2517-25. doi: 10.1021/nl801596a. Epub 2008 Jul 12.


Silica is a promising carrier material for nanoparticle-facilitated drug delivery, gene therapy, and molecular imaging. Understanding of their pharmacokinetics is important to resolve bioapplicability issues. Here we report an extensive study on bare and lipid-coated silica nanoparticles in mice. Results obtained by use of a wide variety of techniques (fluorescence imaging, inductively coupled plasma mass spectrometry, magnetic resonance imaging, confocal laser scanning microscopy, and transmission electron microscopy) showed that the lipid coating, which enables straightforward functionalization and introduction of multiple properties, increases bioapplicability and improves pharmacokinetics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism*
  • Biocompatible Materials / pharmacokinetics*
  • Lipids / chemistry*
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / metabolism*
  • Silicon Dioxide / pharmacokinetics*


  • Biocompatible Materials
  • Lipids
  • Silicon Dioxide