Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

J Cell Mol Med. 2008 Dec;12(6A):2263-80. doi: 10.1111/j.1582-4934.2008.00402.x. Epub 2008 Jun 27.


Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro-survival strategies are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Apoptosis / physiology
  • Autophagy / physiology
  • Brain Ischemia / metabolism
  • Brain Ischemia / pathology
  • Cell Death / physiology*
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Huntington Disease / metabolism
  • Huntington Disease / pathology
  • Models, Neurological
  • Necrosis
  • Nerve Tissue Proteins / metabolism*
  • Neurodegenerative Diseases / metabolism*
  • Neurodegenerative Diseases / pathology*
  • Neurodegenerative Diseases / therapy
  • Neurons / metabolism*
  • Neurons / pathology*
  • Parkinson Disease / metabolism
  • Parkinson Disease / pathology
  • Proteasome Endopeptidase Complex / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Stress, Physiological
  • Ubiquitin / metabolism


  • Nerve Tissue Proteins
  • Receptors, N-Methyl-D-Aspartate
  • Ubiquitin
  • Proteasome Endopeptidase Complex