The amblyopic deficit for global motion is spatial scale invariant

Vision Res. 2008 Sep;48(19):1965-71. doi: 10.1016/j.visres.2008.06.012. Epub 2008 Jul 26.


Humans with amblyopia display anomalous performance for global motion discrimination. Attempts have been made to rule out an explanation based solely on the visibility loss in lower visual areas. However, it remains a possibility that the altered scale over which local motion is processed in V1 might lead to reduced efficiency of global motion processing in extra-striate cortex. We use stimuli composed of spatial frequency bandpass elements, equated for visibility, to show that the global motion deficit in amblyopia for both fellow and amblyopic eyes is still present once impairments in low-level processing have been factored out. This residual deficit appears to be spatial scale invariant and the relative deficit between the eyes shows a dependence on stimulus speed. We believe that this rules out an explanation of the amblyopic global motion deficit based solely on local motion input. We suggest instead that, in addition to low-level deficits, motion processing in a broadband, extra-striate, global motion mechanism is impaired in amblyopia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amblyopia / psychology*
  • Contrast Sensitivity
  • Humans
  • Middle Aged
  • Motion Perception*
  • Perceptual Disorders / etiology*
  • Perceptual Disorders / psychology
  • Photic Stimulation / methods
  • Psychophysics
  • Sensory Thresholds
  • Space Perception