Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate

Clin Exp Dermatol. 2009 Jan;34(1):39-42. doi: 10.1111/j.1365-2230.2008.02877.x. Epub 2008 Jul 4.


Calciphylaxis is a rare, life-threatening cause of skin necrosis. The condition is primarily reported in patients with end-stage renal disease, and is associated with significant morbidity and mortality. Treatment has mainly been empirical. We report a case of calciphylaxis in a patient with normal renal function and hypoparathyroidism, who responded to treatment with sodium thiosulfate. To our knowledge, this is the first reported case of the use of sodium thiosulfate to treat calciphylaxis in a patient with normal renal function.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Wall
  • Adult
  • Anticoagulants / adverse effects
  • Calciphylaxis / diagnostic imaging
  • Calciphylaxis / drug therapy*
  • Calciphylaxis / pathology
  • Calcium / adverse effects
  • Chelating Agents / therapeutic use*
  • Female
  • Humans
  • Hypoparathyroidism / complications
  • Kidney / physiology*
  • Obesity / complications
  • Thiosulfates / therapeutic use*
  • Treatment Outcome
  • Warfarin / adverse effects
  • Xeroradiography / methods


  • Anticoagulants
  • Chelating Agents
  • Thiosulfates
  • Warfarin
  • sodium thiosulfate
  • Calcium