Hypertrophy and fibrosis in the cardiomyopathy of uremia--beyond coronary heart disease

Semin Dial. Jul-Aug 2008;21(4):308-18. doi: 10.1111/j.1525-139X.2008.00454.x. Epub 2008 Jul 8.


Cardiac disease is the leading cause of death in uremic patients. In contrast to previous opinion, coronary events account for a relatively small proportion of cardiac deaths, the most common causes being sudden death and heart failure. Against this background the current text will discuss noncoronary cardiac pathology, specifically the pathogenesis and the morphological findings caused by (pathological) cardiac hypertrophy, cardiac interstitial fibrosis and microvascular disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomyopathy, Hypertrophic / epidemiology
  • Cardiomyopathy, Hypertrophic / etiology*
  • Coronary Disease / epidemiology
  • Coronary Disease / etiology*
  • Death, Sudden, Cardiac / epidemiology
  • Disease Progression
  • Fibrosis / epidemiology
  • Fibrosis / etiology
  • Humans
  • Incidence
  • Myocardium / pathology*
  • Survival Rate
  • United States / epidemiology
  • Uremia / complications*