Actinomycetoma with negative culture: a therapeutic challenge

Dermatol Online J. 2008 Apr 15;14(4):5.


Nocardia, Actinomyces, and Streptomyces species comprise the three broad classes of organisms that are causative for bacterial mycetoma. Although culture and molecular laboratory studies can usually identify the precise etiologic agent in bacterial mycetoma, occasionally these methods fail to clarify this situation. We report a classic clinical case of this infectious disease where usual diagnostic methods failed to identify the responsible organism, and discuss the empiric approach to such cases.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Emigrants and Immigrants
  • False Negative Reactions
  • Forearm / microbiology
  • Forearm / pathology
  • Humans
  • Male
  • Microbiological Techniques
  • Middle Aged
  • Mycetoma / diagnosis*
  • Mycetoma / drug therapy
  • Mycetoma / microbiology
  • Nocardia / isolation & purification*
  • Skin / microbiology*
  • Skin / pathology
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use


  • Anti-Bacterial Agents
  • Trimethoprim, Sulfamethoxazole Drug Combination