Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3

Angiology. Aug-Sep 2008;59(4):408-14. doi: 10.1177/0003319708321801. Epub 2008 Jul 15.

Abstract

This study investigated the efficacy of isotonic bioflavonoid supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous oxygen partial pressure and decreased pCO(2). With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk factors by daily supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Biomarkers / blood
  • Blood Pressure / drug effects
  • Cardiovascular Agents / adverse effects
  • Cardiovascular Agents / therapeutic use*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / prevention & control*
  • Carotid Arteries / drug effects
  • Carotid Arteries / physiopathology
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Flavonoids / adverse effects
  • Flavonoids / therapeutic use*
  • Forearm / blood supply
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Metabolic Syndrome / complications
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / metabolism
  • Metabolic Syndrome / physiopathology
  • Microcirculation / drug effects
  • Microcirculation / physiopathology
  • Middle Aged
  • Oxidative Stress / drug effects
  • Plant Extracts / therapeutic use*
  • Regional Blood Flow / drug effects
  • Risk Factors
  • Skin / blood supply
  • Stroke Volume / drug effects
  • Treatment Outcome
  • Ultrasonography, Doppler, Duplex
  • Vasodilation / drug effects
  • Ventricular Function, Left / drug effects

Substances

  • Biomarkers
  • Cardiovascular Agents
  • Flavonoids
  • Plant Extracts