Treatment of Constitutional Growth Delay in Prepubertal Boys With a Prolonged Course of Low Dose Oxandrolone

Arch Dis Child. 1991 Jul;66(7):841-3. doi: 10.1136/adc.66.7.841.

Abstract

Forty six prepubertal boys who had constitutional growth delay were treated with oxandrolone. Mean age at the onset of treatment was 11.9 years (range 9.0-14.0) and bone age delay was 1.9 'years'. The dose of oxandrolone used was a mean of 0.05 mg/kg (range 0.03-0.18) for a mean of 0.9 years (range 0.2-3.6). Height velocity increased from a mean (SD) before treatment of 4.0 (1.0) to 7.5 (1.2) cm/year with oxandrolone. Growth rate was sustained at 7.6 (2.2) cm/year in the period after treatment. Those boys who attained a testicular volume of 4 ml or greater at the end of the treatment period had the most pronounced sustained growth acceleration. Height for bone age SD score did not alter significantly from a mean of -1.0 before treatment to -1.2 after treatment. Oxandrolone is a safe and effective treatment for prepubertal boys with constitutional growth delay.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Body Height
  • Child
  • Drug Administration Schedule
  • Growth Disorders / drug therapy*
  • Humans
  • Male
  • Oxandrolone / administration & dosage
  • Oxandrolone / therapeutic use*
  • Puberty*

Substances

  • Oxandrolone