Acquired aplastic anaemia: still a serious disease

Arch Dis Child. 1991 Jul;66(7):858-61. doi: 10.1136/adc.66.7.858.


Over 15 years, 42 children aged 2-14 years were diagnosed as having acquired aplastic anaemia. Adequate clinical details were available for 38 children who were categorised as very severe (n = 13), severe (n = 16), or nonsevere (n = 9) by the modified Camitta criteria. Treatment varied over the study period. Seven children received a bone marrow allograft from a full match family donor and three a matched unrelated donor transplant after failed treatment with antilymphocyte globulin. The remainder were treated with antilymphocyte globulin (n = 11), antilymphocyte globulin and oxymetholone (n = 4), oxymetholone with or without prednisolone (n = 12), or supportive treatment alone (n = 1). With a minimum follow up of one year since treatment, the five year survival was 70% for bone marrow transplantation with a family donor, 30% for antilymphocyte globulin, and 25% for oxymetholone. All three children with a matched unrelated donor transplant died. The prognosis of acquired aplastic anaemia remains poor for most children and new approaches to treatment are urgently required.

MeSH terms

  • Adolescent
  • Anemia, Aplastic / mortality
  • Anemia, Aplastic / surgery
  • Anemia, Aplastic / therapy*
  • Bone Marrow Transplantation
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppression Therapy
  • Male
  • Oxymetholone / therapeutic use
  • Prognosis


  • Oxymetholone