Systems biology: On the cell cycle and its switches

Nature. 2008 Jul 17;454(7202):288-9. doi: 10.1038/454288a.


For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

Publication types

  • News
  • Comment

MeSH terms

  • Cell Cycle / physiology*
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Feedback, Physiological / physiology
  • Gene Expression Regulation
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / physiology
  • Systems Biology*


  • Cell Cycle Proteins