On the correlation between T(2) and tissue diffusion coefficients in exercised muscle: quantitative measurements at 3T within the tibialis anterior

MAGMA. 2008 Jul;21(4):273-8. doi: 10.1007/s10334-008-0120-8. Epub 2008 Jul 17.


Purpose: To assess the transverse relaxation time T(2) and diffusion coefficient D before and following exercise in the tibialis anterior muscle and determine whether T(2) and D values were correlated.

Methods: Measurements of T(2) and D were performed at 3 T within axial slices through the calf muscles of six healthy volunteers at 95 s intervals before and for 10-12 min after a dorsiflexion exercise to exhaustion.

Results: The mean +/- standard deviation (SD) of T(2) and D before exercise were 32 +/- 1.55 ms and 1.52 +/- 0.15 mum(2)/ms, and after exercise were 43 +/- 2.5 ms and 1.72 +/- 0.13 mum(2)/ms, respectively. The mean +/- SD inter-individual recovery times of the % change in T(2) and D after exercise were 7.9 +/- 4.2 and 10.9 +/- 7.0 min, respectively. The T(2) and D values showed a significant correlation throughout the experiments (r (2) = 0.45).

Conclusions: The increase in T(2) of skeletal muscle after exercise is correlated with the increase of the diffusion coefficient D and the recovery times appear similar, indicating that any model used to explain T(2) increases with exercise must also account for increased diffusion coefficients.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Exercise / physiology*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Muscle Contraction / physiology*
  • Muscle, Skeletal / anatomy & histology
  • Muscle, Skeletal / physiology*