[Survival of transgenic mouse embryos carrying different genetic constructs]

Ontogenez. 2008 May-Jun;39(3):208-11.
[Article in Russian]


The survival of transgenic mouse embryos was studied as a function of the transgene structure. The data obtained indicate that the introduction of a chromosomal DNA fragment providing for the anchoring of interphase chromosomes on the nuclear envelope increases the efficiency of transgenesis in mice threefold due to their increased viability.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Chromosomes, Mammalian / genetics*
  • Chromosomes, Mammalian / metabolism
  • Embryo, Mammalian / cytology
  • Embryo, Mammalian / metabolism*
  • Female
  • Gene Transfer Techniques*
  • Interphase / physiology*
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Transgenic
  • Nuclear Envelope / genetics
  • Nuclear Envelope / metabolism*
  • Transgenes / physiology*