[Survival of transgenic mouse embryos carrying different genetic constructs]

M V Glazkov; S F Drozd; P K Golovatenko-Abramov; M Iu Martynova; A P Nesterova

[Survival of transgenic mouse embryos carrying different genetic constructs]

Ontogenez. 2008 May-Jun;39(3):208-11.

[Article in Russian]

Authors

M V Glazkov, S F Drozd, P K Golovatenko-Abramov, M Iu Martynova, A P Nesterova

PMID: 18634333

Abstract

The survival of transgenic mouse embryos was studied as a function of the transgene structure. The data obtained indicate that the introduction of a chromosomal DNA fragment providing for the anchoring of interphase chromosomes on the nuclear envelope increases the efficiency of transgenesis in mice threefold due to their increased viability.

Publication types

English Abstract

MeSH terms

Animals
Chromosomes, Mammalian / genetics*
Chromosomes, Mammalian / metabolism
Embryo, Mammalian / cytology
Embryo, Mammalian / metabolism*
Female
Gene Transfer Techniques*
Interphase / physiology*
Male
Mice
Mice, Inbred CBA
Mice, Transgenic
Nuclear Envelope / genetics
Nuclear Envelope / metabolism*
Transgenes / physiology*