The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study

Anesth Analg. 2008 Jul;107(1):167-70. doi: 10.1213/ane.0b013e3181732dc2.


Background: Agitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.

Methods: This was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.

Results: Ramsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.

Conclusion: This study shows that dexmedetomidine is an effective sedative drug for patients with NIV.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Dexmedetomidine / adverse effects
  • Dexmedetomidine / therapeutic use*
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Intensive Care Units
  • Male
  • Middle Aged
  • Prospective Studies
  • Psychomotor Agitation / prevention & control
  • Respiration, Artificial / methods*


  • Hypnotics and Sedatives
  • Dexmedetomidine