No evidence of association between frontotemporal dementia and major European mtDNA haplogroups

Eur J Neurol. 2008 Sep;15(9):1006-8. doi: 10.1111/j.1468-1331.2008.02222.x. Epub 2008 Jul 10.

Abstract

Background and purpose: Mitochondrial DNA (mtDNA) inherited variability (haplogroup/sub-haplogroup) is currently emerging as not being neutral with respect to several complex traits like neurodegenerative diseases. Here we investigated the association of European mtDNA haplogroups/sub-haplogroups with frontotemporal dementia (FTD).

Method and results: A case-control study was carried out on 114 patients with FTD (68 sporadic and 46 familial) and 180 controls, matched for age, gender and ethnicity. No association was found.

Conclusions: European mtDNA haplogroups/sub-haplogroups are unlikely to play a major role in the risk of developing the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • DNA, Mitochondrial / classification
  • DNA, Mitochondrial / genetics*
  • Dementia / epidemiology
  • Dementia / genetics*
  • Ethnic Groups / genetics
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes / genetics*
  • Humans
  • Italy / epidemiology
  • Male
  • Middle Aged

Substances

  • DNA, Mitochondrial