Mechanism for gastric cancer development by Helicobacter pylori infection

J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1175-81. doi: 10.1111/j.1440-1746.2008.05472.x. Epub 2008 Jun 10.


Helicobacter pylori (H. pylori) infection plays a crucial role in the development of gastric cancer. There are two major pathways for the development of gastric cancer by H. pylori infection: the indirect action of H. pylori on gastric epithelial cells through inflammation, and the direct action of the bacteria on epithelial cells through the induction of protein modulation and gene mutation. Both pathways work together to promote gastric carcinogenesis.

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / immunology*
  • Gastric Mucosa / microbiology
  • Helicobacter Infections / complications*
  • Helicobacter pylori*
  • Humans
  • Stomach Neoplasms / etiology
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / microbiology*