Neuroendocrine modulation of cancer progression

Brain Behav Immun. 2009 Jan;23(1):10-5. doi: 10.1016/j.bbi.2008.06.007. Epub 2008 Jun 27.


Clinical and animal studies now support the notion that psychological factors such as stress, chronic depression, and lack of social support might promote tumor growth and progression. Recently, cellular and molecular studies have started to identify biological processes that could mediate such effects. This review provides a mechanistic understanding of the relationship between biological and behavioral influences in cancer and points to more comprehensive behavioral and pharmacological approaches for better patient outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Depression / physiopathology
  • Disease Progression
  • Humans
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Neuroimmunomodulation / immunology
  • Neuroimmunomodulation / physiology
  • Neurosecretory Systems / immunology
  • Neurosecretory Systems / physiopathology*
  • Psychoneuroimmunology
  • Stress, Psychological / immunology
  • Stress, Psychological / physiopathology