A pyrazole derivative of curcumin enhances memory

Neurobiol Aging. 2010 Apr;31(4):706-9. doi: 10.1016/j.neurobiolaging.2008.05.020. Epub 2008 Jul 17.

Abstract

Reduced cognitive function is associated with Alzheimer's and Parkinson's diseases as well as brain trauma and ischemia. However, there are few compounds that enhance memory and are also orally active. We recently synthesized a pyrazole derivative of curcumin called CNB-001 that enhances the activity of Ca(2+)/calmodulin dependent protein kinase II (CaMKII). Since CaMKII plays a central role in long-term potentiation (LTP) and memory, it was asked if CNB-001 can facilitate the induction of LTP in rat hippocampal slices and enhance memory in a rat object recognition test. It is shown that CNB-001 enhances both LTP and memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / drug effects
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism
  • Cognition Disorders / drug therapy
  • Cognition Disorders / metabolism
  • Cognition Disorders / physiopathology
  • Curcumin / analogs & derivatives*
  • Curcumin / chemistry
  • Curcumin / pharmacology
  • Curcumin / therapeutic use
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Memory Disorders / drug therapy
  • Memory Disorders / metabolism
  • Memory Disorders / physiopathology
  • Nerve Degeneration / drug therapy
  • Nerve Degeneration / physiopathology
  • Nerve Degeneration / prevention & control
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / physiopathology
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology*
  • Neuropsychological Tests
  • Nootropic Agents / chemistry
  • Nootropic Agents / pharmacology*
  • Organ Culture Techniques
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Pyrazoles / therapeutic use
  • Rats
  • Rats, Wistar
  • Recognition, Psychology / drug effects
  • Recognition, Psychology / physiology
  • Treatment Outcome

Substances

  • CNB 001
  • Neuroprotective Agents
  • Nootropic Agents
  • Pyrazoles
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Curcumin