PIGS: automatic prediction of antibody structures

Bioinformatics. 2008 Sep 1;24(17):1953-4. doi: 10.1093/bioinformatics/btn341. Epub 2008 Jul 19.


We describe a web server for the automatic prediction of immunoglobulin variable domains based on the canonical structure model. The server is user-friendly and flexible. It allows the user to select the templates for the frameworks and the loops using different strategies. The final output is a full-fledged 3D model of the variable domains of the target immunoglobulin.

Availability: The server is openly accessible to academic users at the address: http://arianna.bio.uniroma1.it/pigs. It does not require registration and there is no limit to the number of sequences that can be submitted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Antibodies / chemistry*
  • Antibodies / ultrastructure*
  • Computer Simulation
  • Immunoglobulin Variable Region / chemistry*
  • Immunoglobulin Variable Region / ultrastructure*
  • Internet
  • Models, Chemical*
  • Models, Molecular*
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Structure, Tertiary
  • Sequence Analysis, Protein / methods
  • Software*
  • User-Computer Interface


  • Antibodies
  • Immunoglobulin Variable Region