Adrenocorticotropin. 48. Synthesis and biological activity of (15, 16-D-lysine, 17, 18-D-arginine)-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin

Int J Pept Protein Res. 1976;8(6):589-95. doi: 10.1111/j.1399-3011.1976.tb02539.x.

Abstract

The peptide [15, 16-D-lysine, 17, 18-D-arginine]-adrenocorticotropin-(1-19) and an all-D-retropeptide related to the amino terminal octadecapeptide of adrenocorticotropin have been synthesized by the solid-phase method. The nonadecapeptide was shown to possess 10-15% of the steroidogenic activity and 3% of the lipolytic activity of adrenocorticotropin-(1-19). The all-D-retropeptide showed no activity and exhibited no inhibitory activity in steroidogenesis and lipolysis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenocorticotropic Hormone / analysis
  • Adrenocorticotropic Hormone / chemical synthesis*
  • Adrenocorticotropic Hormone / pharmacology
  • Amino Acid Sequence
  • Animals
  • Arginine
  • Electrophoresis, Paper
  • Lysine
  • Peptide Termination Factors
  • Peptides / analysis
  • Peptides / chemical synthesis*
  • Peptides / pharmacology
  • Rats

Substances

  • Peptide Termination Factors
  • Peptides
  • Adrenocorticotropic Hormone
  • Arginine
  • Lysine