Anticipating issues related to increasing preimplantation genetic diagnosis use: a research agenda

Reprod Biomed Online. 2008:17 Suppl 1:33-42. doi: 10.1016/s1472-6483(10)60188-5.


Increasing use of preimplantation genetic diagnosis (PGD) poses numerous clinical, social, psychological, ethical, legal and policy dilemmas, many of which have received little attention. Patients and providers are now considering and using PGD for a widening array of genetic disorders, and patients may increasingly seek 'designer babies.' In the USA, although governmental oversight policies have been discussed, few specific guidelines exist. Hence, increasingly, patients and providers will face challenging ethical and policy questions of when and for whom to use PGD, and how it should be financed. These issues should be better clarified and addressed through collection of data concerning the current use of PGD in the USA, including factors involved in decision making about PGD use, as well as the education of the various communities that are, and should be, involved in its implementation. Improved understanding of these issues will ultimately enhance the development and implementation of future clinical guidelines and policies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Decision Making
  • Ethics, Medical
  • Female
  • Fertilization in Vitro / ethics
  • Fertilization in Vitro / methods
  • Genetic Predisposition to Disease / genetics
  • Government Regulation
  • Humans
  • Male
  • Maternal Age
  • Policy Making
  • Preimplantation Diagnosis / economics
  • Preimplantation Diagnosis / ethics*
  • Professional-Patient Relations
  • Public Policy
  • Reproductive Techniques, Assisted / economics
  • Reproductive Techniques, Assisted / ethics*
  • Sex Preselection / ethics