Animal models of wound healing: utility in transgenic mice

J Biomater Sci Polym Ed. 2008;19(8):989-1005. doi: 10.1163/156856208784909327.

Abstract

Transgenic and knockout mouse technology represents a powerful tool for exploring the molecular pathways behind the wound healing process. The design and utilization of mouse wound healing models must be approached mindful of limitations of both the transgenic technology and the models themselves in order to continue generating useful information from studies with transgenic mice. A battery of standard and impaired wound healing models, when used in a systematic and combinatorial fashion, should yield significant contributions to wound healing research.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Disease Models, Animal
  • Epithelium / pathology
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Animal
  • Models, Biological
  • Skin / pathology
  • Wound Healing*

Substances

  • Biocompatible Materials