Structural Proteomics of Dengue Virus

Curr Opin Microbiol. 2008 Aug;11(4):369-77. doi: 10.1016/j.mib.2008.06.004. Epub 2008 Jul 31.

Abstract

In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the recently solved structures of NS5 methyltransferase and polymerase domains. These structures provide a basis for describing function and predicting putative host interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Dengue Virus / chemistry*
  • Dengue Virus / genetics
  • Dengue Virus / physiology*
  • Models, Molecular
  • Protein Structure, Quaternary
  • Proteomics
  • Viral Nonstructural Proteins / chemistry*
  • Viral Nonstructural Proteins / genetics
  • Virus Assembly*

Substances

  • Viral Nonstructural Proteins