From KISS1 to kisspeptins: An historical perspective and suggested nomenclature

Peptides. 2009 Jan;30(1):4-9. doi: 10.1016/j.peptides.2008.06.016. Epub 2008 Jul 3.


The cancer suppressor gene, KISS1, was initially described as having an important role in inhibiting cancer metastasis. Since then, KISS1 and its receptor, KISS1R, have been shown to play a key role in controlling the onset of puberty of reproductive physiology in the human and other species. Recent studies have also linked KISS1/kisspeptin/KISS1R to other processes, such as vasoconstriction, aging, adipocyte physiology, and perhaps as a molecular conduit linking metabolism and reproduction. This article highlights the history of KISS1/kisspeptin/KISS1R biology and proposes a consensus for nomenclature of the key molecules in this signaling pathway.

MeSH terms

  • Animals
  • Humans
  • Hypothalamus / cytology
  • Hypothalamus / metabolism
  • Kisspeptins
  • Receptors, G-Protein-Coupled* / genetics
  • Receptors, G-Protein-Coupled* / metabolism
  • Receptors, Kisspeptin-1
  • Reproduction / physiology
  • Signal Transduction / physiology
  • Terminology as Topic*
  • Tumor Suppressor Proteins* / genetics
  • Tumor Suppressor Proteins* / metabolism


  • KISS1 protein, human
  • KISS1R protein, human
  • Kisspeptins
  • Receptors, G-Protein-Coupled
  • Receptors, Kisspeptin-1
  • Tumor Suppressor Proteins