Smqnr, a new chromosome-carried quinolone resistance gene in Stenotrophomonas maltophilia

Antimicrob Agents Chemother. 2008 Oct;52(10):3823-5. doi: 10.1128/AAC.00026-08. Epub 2008 Jul 21.

Abstract

A new chromosome-carried quinolone resistance gene from Stenotrophomonas maltophilia, Smqnr, was characterized. The gene was present in type strain CCUG 5866 and was also detected in 24 clinical isolates and showed some allelic diversity. The expression of Smqnr in Escherichia coli decreased the susceptibilities of the E. coli isolates to several fluoroquinolones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Anti-Bacterial Agents / pharmacology
  • Base Sequence
  • Chromosomes, Bacterial / genetics
  • DNA Primers / genetics
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial / genetics*
  • Fluoroquinolones / pharmacology*
  • Genes, Bacterial*
  • Gram-Negative Bacterial Infections / drug therapy
  • Gram-Negative Bacterial Infections / microbiology
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Stenotrophomonas maltophilia / drug effects*
  • Stenotrophomonas maltophilia / genetics*
  • Stenotrophomonas maltophilia / isolation & purification

Substances

  • Anti-Bacterial Agents
  • DNA Primers
  • DNA, Bacterial
  • Fluoroquinolones

Associated data

  • GENBANK/AB430839
  • GENBANK/AB430840
  • GENBANK/AB430841
  • GENBANK/AB430842
  • GENBANK/AB430843
  • GENBANK/AB430845
  • GENBANK/AB430846
  • GENBANK/AB430847
  • GENBANK/AB430848
  • GENBANK/AB430849
  • GENBANK/AB430850