Renal Hepatitis C in the Absence of Detectable Serum or Hepatic Virus

Liver Int. 2008 Jul;28(6):889-91. doi: 10.1111/j.1478-3231.2008.01672.x.


We report an apparently unique case where hepatitis C virus (HCV) RNA was identified in renal tissue from a patient with membranoproliferative glomerulonephritis and treated chronic hepatitis C, despite the absence of detectable virus in the serum or liver (COBAS Amplicor qualitative assay, lower limit of detection 50 IU/ml). The implications of this finding are discussed, with particular reference to current concepts regarding 'occult' hepatitis C infection.

Publication types

  • Case Reports

MeSH terms

  • Glomerulonephritis, Membranoproliferative / blood
  • Glomerulonephritis, Membranoproliferative / pathology
  • Glomerulonephritis, Membranoproliferative / virology*
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification*
  • Hepatitis C, Chronic / blood
  • Hepatitis C, Chronic / complications*
  • Hepatitis C, Chronic / pathology
  • Humans
  • Kidney / pathology
  • Kidney / virology*
  • Male
  • Middle Aged
  • RNA, Viral / blood


  • RNA, Viral