Microbleeds in moyamoya disease: susceptibility-weighted imaging versus T2*-weighted imaging at 3 Tesla

Invest Radiol. 2008 Aug;43(8):574-9. doi: 10.1097/RLI.0b013e31817fb432.


Objectives: To prospectively evaluate differences in detectability of cerebral microbleeds (MBs) in Moyamoya disease (MMD) on susceptibility-weighted imaging (SWI) and T2*-weighted imaging (T2*WI) at 3 T.

Materials and methods: SWI and T2*WI were applied for 50 consecutive MMD patients. MB was defined as a very low signal intensity area in each sequence without continuity from surrounding vessel structures. Numbers of MBs were compared between the 2 sequences. To assess visualization, a grading score was assigned to each MB from Grade 3 (prominent) to Grade 0 (normal-appearing) on SWI and T2*WI, respectively, and were compared by Wilcoxon signed rank test.

Results: A total of 37 MBs were detected in 21 patients (42%) on SWI, compared with 27 MBs in 16 patients (32%) on T2*WI, with significant difference in number of MBs between the 2 sequences (P = 0.002). Lesions displayed greater visual grading score on SWI than on T2*WI (P < 0.0001).

Conclusions: SWI offers better detectability of MBs in MMD than T2*WI at 3 T.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebral Hemorrhage / diagnosis*
  • Child
  • Female
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Moyamoya Disease / complications*
  • Prospective Studies