Natural inhibitors of DNA topoisomerase I with cytotoxicities

Chem Biodivers. 2008 Jul;5(7):1364-8. doi: 10.1002/cbdv.200890124.

Abstract

DNA Topoisomerase I can cause DNA breaks and play a key role during cell proliferation and differentiation. It is an important target for anticancer agents. While screening for anticancer compounds, seven natural compounds, 1-7, showed potent cytotoxicities against a panel of ten cancer cell lines. Moreover, an inhibition assay demonstrated that they are also DNA topoisomerase I inhibitors, in which inhibitors 1-5 are new ones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • Topoisomerase I Inhibitors*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Topoisomerase I Inhibitors