Streptopyrrolidine, an angiogenesis inhibitor from a marine-derived Streptomyces sp. KORDI-3973

Phytochemistry. 2008 Sep;69(12):2363-6. doi: 10.1016/j.phytochem.2008.05.020. Epub 2008 Jul 21.

Abstract

Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Dimethyl Sulfoxide
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Neovascularization, Pathologic / prevention & control
  • Pyrrolidines / chemistry
  • Pyrrolidines / pharmacology*
  • Seawater / microbiology
  • Spectrophotometry, Infrared
  • Streptomyces* / isolation & purification
  • Umbilical Veins

Substances

  • Angiogenesis Inhibitors
  • Pyrrolidines
  • Dimethyl Sulfoxide