Abstract
Streptopyrrolidine, a benzyl pyrrolidine derivative, was isolated as an angiogenesis inhibitor from the fermentation broth of a marine Streptomyces sp. isolated from the deep sea sediment. Its structure was elucidated by extensive 2D NMR and mass spectroscopic analyses. Streptopyrrolidine exhibited significant anti-angiogenesis activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / pharmacology*
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Dimethyl Sulfoxide
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Neovascularization, Pathologic / prevention & control
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacology*
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Seawater / microbiology
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Spectrophotometry, Infrared
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Streptomyces* / isolation & purification
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Umbilical Veins
Substances
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Angiogenesis Inhibitors
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Pyrrolidines
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Dimethyl Sulfoxide